Today, DNA identity testing is widely used in the field of forensics and paternity identification. Other clinical applications are based upon the methods developed for forensic testing. They include assessment of donor hematopoietic engraftment after bone marrow transplantation and chimerism analysis after solid organ transplantation. Other uses include confirming a diagnosis of hydatidiform mole and resolving issues of specimen identity in cases of specimen mislabeling or misidentification. Finally, DNA identity testing can be used to evaluate tumor transmission after transplantation and thus determine whether a malignancy is of donor or recipient origin.VNTR and STR are useful for identity testing because they are polymorphic and are inherited in a mendelian fashion. Each individual inherits one paternal and one maternal allele of a specific STR locus, leading to further diversity in STR pattern.
Article: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1200713
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